5-BROMO-4-(3,4-DIMETHOXYPHENYL)THIAZOL-2-AMINE

5-Bromo-4-(3,4-dimethoxyphenyl)thiazol-2-amine

In the title compound, C11H11BrN2O2S, the thiazole ring makes a dihedral angle of 53.16 (11)° with the adjacent benzene ring.The two methoxy groups are slightly Seasonal twisted from the attached benzene ring with C—O—C—C torsion angles of −9.2 (3) and −5.5 (3)

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Targeting IGF1/IGF1r signaling relieve pain and autophagic dysfunction in NTG-induced chronic migraine model of mice

Abstract Background Chronic migraine is a severe and common neurological disorder, yet its precise physiological mechanisms Seasonal remain unclear.The IGF1/IGF1r signaling pathway plays a crucial role in pain modulation.Studies have shown that IGF1, by binding to its receptor IGF1r, activates a series of downstream signaling cascades involved in n

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